Research shows that the drug activates the cannabinoid neurotransmitter system (which protects the brain), and this stimulates the cholinergic system (which controls memory and learning ...

Drugs acting on the cholinergic system can improve or worsen cognitive abilities, and their effects are particularly pronounced in frail elderly individuals and patients with Alzheimer disease.

Although compounds with a combined cholinergic–glutamatergic action have been trialed, none has yet been successful in the later stages of development (Table 4). Consequently, combination ...

Nicotine withdrawal induces behavioral symptoms such as tremors and shaking. Suppressing striatal cholinergic interneurons or administering the muscarinic antagonist Procyclidine significantly ...

The research team pinpointed the role of striatal cholinergic interneurons in nicotine withdrawal symptoms. Through experiments on mice, they selectively inhibited sodium channel expression in the ...

While the precise mechanism of galantamine’s action is unknown, it is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the ...

Acetylcholine in the prefrontal cortex modulates the impact of surprising outcomes on learning and decision-making.