The protein kinase C (PKC) signaling cascade has been identified as a direct biochemical target for the treatment of ... of 16 inpatients in the manic phase of bipolar disorder.

[35,36,37,38] Lowering the daily dosage, and thereby decreasing the serum concentration of lithium, results in decreased efficacy in the treatment of both mania and depressive symptoms.

it was noted that the treatment of mania is fairly standardized throughout the world, but the treatment of bipolar depression varies substantially regionally. This group took as its mission to ...

Our understanding of bipolar disorder and effective ways to manage it continue to broaden, with patients as active partners in maintaining stability. Comparisons between what we know now versus what ...