The flavonoid silymarin and one of its structural components, silibinin, are substances with documented hepatoprotective properties. Their mechanisms of action are still poorly understood.

In the most rigorous trial to date, oral silymarin was not superior to placebo in decreasing disease activity. Silymarin is a botanical extract of milk thistle commonly used by patients with liver ...

Since an oxidative stress and dietary deficiency of choline have been implicated in the pathophysiology of hepatic insult, the use of natural compounds like Silymarin, Choline and Ursodeoxycholic acid ...

This study aimed to investigate the hepatoprotective potential of dapagliflozin and silymarin alone and in combination against CCl 4-induced hepatotoxicity in Wistar rats. Methods 30 adult Wistar rats ...