The diagnostic pathway begins with a chief complaint from a patient. The clinician creates an initial differential diagnosis based on knowledge of disease incidence in the population of interest (i.e.

We used Stata software (V.14.0) to conduct the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic OR (DOR), pretest probability, post-test ...

Each chapter focuses on a presenting problem rather than on a specific disease and begins with a box of key points that include statements about pretest probability and diagnostic strategies.

10 Often, such errors reflect ordering diagnostic tests in the setting of low pretest probability of a disease, increasing the likelihood of a false positive or overdiagnosis. A well-known example is ...

Test formularies should be scrutinised in view of the setting of care, with interventions to focus rational testing towards those with higher pretest probabilities, while improving interpretation and ...

Reporting test-result interval specific LRs can give additional diagnostic depth to a lab result.3 The LR (probability of a specific result in patients divided by the probability of the same result in ...

The diagnostic value of each symptom can then be added to the previous symptom in an additive process where the post-test probability from the previous symptom serves as the pretest probability of the ...

Objectives: To assess whether multislice computed tomography coronary angiography (MSCTA) may be useful for risk stratification of patients with suspected coronary artery disease (CAD) at intermediate ...

Step 3: basic testing The main novelties regarding the assessment of patients with angina or dyspnea and suspected CAD focus on assessing the pretest probability of CAD and selecting the diagnostic ...

LRs combine sensitivity and specificity to quantify how helpful a new diagnostic test is in changing (increasing or decreasing) the probability of having a disease compared with the prevalence of that ...

This study determined the diagnostic utility of clinical tests for GT ... Results Pain reported within 30 s of standing on the affected limb conclusively moves a (nominal) 50% pretest probability of ...

In children with a very low pretest probability of disease, routine diagnostic testing is not necessary. In fact, in such children, an indiscriminate approach to diagnostic testing might lead to ...