A REVIEW of the voluminous literature on the subject of anal pruritus reveals that nearly as many theories regarding the etiology of this condition have been advanced and methods of treatment ...

The treatment of pruritus ani depends on the cause of the symptoms. The skin coming into contact with fecal material, either in large or small amounts, is a common cause of pruritus ani.

Of the 510,000 PBC patients, 240,000 will experience cholestatic pruritus. The FDA granted linerixibat orphan drug designation in the treatment of PBC and associated cholestatic pruritus in 2019.