Medically reviewed by Daniel Combs, MD Benadryl (diphenhydramine) is an over-the-counter (OTC) antihistamine commonly used to ...

Last month, the U.S. Food and Drug Administration proposed removing phenylephrine -- an active ingredient in hundreds of over-the-counter medications, including some versions of Tylenol, Benadryl ...

commonly sold as Benadryl, in Abigail’s system. During the trial, the defense argued the drug may have been ingested through the mother’s breastmilk, as she had been taking Tylenol PM.