Add several cups of white vinegar to the water reservoir in your Mr. Coffee® Simple Brew 5-Cup Programmable Coffee Maker and run it like you would for a normal pot of coffee. Then, once the brew process is complete, let the cleaner or vinegar sit in the carafe where it will continue cleaning.

Mix equal parts water and white vinegar, then use it to run half of a brew cycle. Let the brewed vinegar solution sit in the pot for 1 hour, and then run the other half of the brew cycle. Pour the vinegar solution into the sink, then run 3 brew cycles using clean water to rinse out the machine.