The Nanoknife procedure, also known as irreversible electroporation (IRE), is a minimally invasive treatment option for prostate cancer that utilizes electrical pulses to induce cell death in cancerous tissue. During the procedure, electrodes are placed around the tumor, and short bursts of high-voltage electrical energy are delivered, creating tiny pores in the cell membranes of cancer cells. This disrupts their ability to maintain homeostasis, leading to cell death while sparing surrounding healthy tissue and structures, such as nerves and blood vessels. The Nanoknife can be particularly beneficial for patients with localized prostate cancer who may not be ideal candidates for traditional surgical options or radiation therapy. It offers the advantage of a shorter recovery time and fewer side effects compared to more invasive treatments, making it an appealing choice for some patients looking to manage their cancer effectively while preserving quality of life.