- Sonidegib is used to treat basal cell carcinoma (BCC; a type of skin cancer) in adults with cancer that has come back after surgery or radiation, or in adults that cannot be treated with surgery or radiation. Sonidegib is in a class of medications called hedgehog pathway inhibitors.
medlineplus.gov/druginfo/meds/a615034.html Sonidegib: Safety and Efficacy in Treatment of Advanced Basal …
Sonidegib (Odomzo ®), an oral smoothened (SMO) antagonist, is indicated for the treatment of adult patients with locally advanced basal cell carcinoma (laBCC) who present recurrence …
Sonidegib - DermNet
See more on dermnetnz.orgIn July 2015 the US FDA (Food and Drug Administration) approved sonidegib (Odomzo®; Novartis, New Jersey, USA) for the treatment of adult patients with locally advanced basal cell carcinoma(BCC). The European Commission approved the use of sonidegib for basal cell carcinomain August 2015. In June 2016, sonid…- Published: Oct 26, 2023
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Full article: Topical hedgehog inhibitors for basal cell carcinoma: …
Mar 8, 2022 · Patidegib and itraconazole are two topical agents emerging as an alternative to oral vismodegib and sonidegib for difficult-to-treat BCCs. Topical medications have limited …
Full article: Sonidegib, a novel smoothened inhibitor for …
Sep 14, 2016 · Sonidegib is a novel smoothened inhibitor that was recently approved by the US Food and Drug Administration. This review focuses on BCC pathogenesis and the clinical efficacy of sonidegib for the treatment of …
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See allTopical Delivery of Hedgehog Inhibitors: Current Status and ...
Murine studies showed that the topical delivery of sonidegib, itraconazole, vitamin D₃ and CUR-61414 led to biological responses and tumor remission. In clinical trials, only topical patidegib …
Key clinical-trial evidence for sonidegib - DermNet
Sonidegib is indicated for the treatment of adult patients with locally advanced basal cell carcinoma (BCC) that has recurred following surgery or radiation therapy, or those who are not …
Update on Hedgehog Pathway Inhibitor Therapy for Patients with …
Topical HPIs have been developed to avoid AEs in patients requiring long-term treatment for multiple BCCs. From the 3 reported phase-2 trials on 3 different HPIs, it can be concluded that …
Sonidegib: MedlinePlus Drug Information
Sonidegib is used to treat basal cell carcinoma (BCC; a type of skin cancer) in adults with cancer that has come back after surgery or radiation, or in adults that cannot be treated with surgery or radiation. Sonidegib is in a class of …
Topical hedgehog inhibitors for basal cell carcinoma: how far …
Sonidegib and vismo-degib are competitive inhibitors of smoothened (SMO) and repre-sent only two FDA-approved Hh inhibitors for the treatment of BCC. These agents are associated with …
Sonidegib, a novel smoothened inhibitor for the treatment of …
Sep 14, 2016 · Sonidegib is a novel smoothened inhibitor that was recently approved by the US Food and Drug Administration. This review focuses on BCC pathogenesis and the clinical …
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